VIP

VIP

5mg

$72.00

$72.00

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide acting as a potent vasodilator, neurotransmitter, and immune regulator. It relaxes smooth muscle, stimulates water/electrolyte secretion in the gut, inhibits gastric acid, and regulates blood pressure. It is used in research for inflammatory conditions (arthritis, COVID-19) and neurological disorders.

Key Functions and Roles

Gastrointestinal System: Stimulates secretion of water, electrolytes, and enzymes into pancreatic juice and bile, while inhibiting gastric acid secretion.
Cardiovascular System: Induces coronary vasodilation and possesses positive inotropic (contraction) and chronotropic (rate) effects on the heart.
Immune System: Acts as an anti-inflammatory and immunomodulatory agent, inhibiting LPS-induced cytokine secretion.

Neurological System: Exhibits neuroprotective properties, including limiting microglial activation in Alzheimer's and protecting dopamine cells in Parkinson's.

VIP in Clinical Context

High Levels: High serum VIP levels (usually $>75 \text{ pg/mL}$) are often associated with VIP-secreting tumors (VIPomas).
Therapeutic Potential: Research indicates potential uses of synthetic analogues in treating respiratory diseases like COPD, asthma, and Pulmonary Arterial Hypertension (PAH), and Chronic Inflammatory Response Syndrome (CIRS) using nasal sprays.
Safety: Pregnant or breastfeeding individuals, and those with low blood pressure, are generally advised to avoid VIP therapy.